Effects of Pb2+ and Cd2+ Heavy Metal Ions on the Rat Liver Mitochondrial ATP-Dependent Potassium Channel


Tojikulova Oysora Jurakulovna*

Bulletin of Pure and Applied Sciences                              

Zoology (Animal Science), Vol.42A, No.2, 

July-December 2023: P.282-286



Tojikulova Oysora Jurakulovna*

Author’s Affiliation:

Samarkand State University, Samarkand, Uzbekistan


*Corresponding author:

Tojikulova Oysora Jurakulovna

Samarkand State University, Samarkand, Uzbekistan

E-mail: otojikulova_81@mail.ru


Article Info:

Received on 23.08.2023

Revised on 07.11.2023

Approved on 13.11.2023

Accepted on 29.11.2023

Published on 20.12.2023

In the article, rat liver of Pb2+ and Cd2+ ionsthe effect on mitoKATP-channel activity in mitochondria was studied.Inhibition of mitoKATF-channel activity was observed experimentally in the presence of 200 μM concentration of ATP in the incubation medium of mitochondria isolated from rat liver.In the absence of ATP in the incubation medium, 8.0 µM concentration of Pb2+ and Cd2+ salts was noted to reduce the permeability of liver mitoKATP-channel activity in both energized and de-energized states compared to the control.   Keywords: Cd2+, Pb2+, Heavy Metals, ATP-Sensitive Potassium Channel, Rat Liver Mitochondria, ATP.