Unravelling the Complexity of SARS-CoV-2 and COVID-19: A Comprehensive Review
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1Aman Bhatia and 2Dr. Gaurav Kapoor*
Bulletin of Pure and Applied Sciences
Zoology (Animal Science), Vol.42A, No.2,
July-December 2023: P.317-339
Description
Description
1Aman Bhatia and 2Dr. Gaurav Kapoor*
| Author’s Affiliation:
1Research Scholar, Department of Zoology, Sardar Patel University, Mandi, Himachal Pradesh 175001, India E-mail: iamaman221b@gmail.com 2Assistant Professor, Department of Zoology, Sardar Patel University, Mandi, Himachal Pradesh 175001, India E-mail: drgauravk@spumandi.ac.in
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| *Corresponding author:
Dr. Gaurav Kapoor Assistant Professor, Department of Zoology, Sardar Patel University, Mandi, Himachal Pradesh 175001, India E-mail: drgauravk@spumandi.ac.in, iamaman221b@gmail.com
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| Article Info:
Received on 12.06.2023 Revised on 22.10.2023 Approved on 02.11.2023 Accepted on 08.11.2023 Published on 20.12.2023 |
Abstract
The recent pandemic of CoVID-19 was due to severe acute respiratory syndrome 2 (SARS-CoV-2) and its various viral variants and their evolutionled to a global pandemic. SARS-CoV-2 is categorised under enveloped viruses consisting of single stranded, non-segmented, linear, positive sense strand RNA which functions as its genetic material. Further sub categorised into five important variants of concern namely, Alpha, Beta, Gamma, Delta, and Omicron. Ribovirus interacts with various receptors in human body most prominently ACE2, APN, NEU-5, results in occurrence and transmission. It is accompanied by induced hypercytokinemia, also known as a cytokine storm. Various cytokine and interlukins associated with it results in acute respiratory distress syndrome (ARDS). This review contains a summarized account of recent advancements regarding epidemiological, clinical and pathological attributes of COVID-19 along with recent progress in treatment and vaccine development.
Keywords:
COVID-19, Cytokine storm, SARS-CoV-2, VOC (variant of concern), Hypercytokinaemia.
