DNA recognitions of Benzimidazole based Bendamustine, Albendazole, and Mebendazole: a Molecular Docking Study
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DNA recognitions of Benzimidazole based Bendamustine, Albendazole, and Mebendazole: a Molecular Docking Study
1Uzma Khan and 2Souvik Sur*
Original Article
Bulletin of Pure and Applied Sciences.
Chemistry , Vol.42 C, No.1
January-June 2023: P.41-45
DOI: 10.48165/bpas.2023.42C.1.7
Description
Description
DNA recognitions of Benzimidazole based Bendamustine, Albendazole, and Mebendazole: a Molecular Docking Study
1Uzma Khan and 2Souvik Sur*
Author Affiliations
1Department of Chemistry, Faculty of Engineering, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh 244001, India,
2Research and Development Center, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh 244001, India
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*Corresponding Author
Souvik Sur, Research and Development Center, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh 244001, India
E-mail: drsouvik.engineering@tmu.ac.in
Received on 25.02.2023, Revised on 03.05.2023, Approved on 11.05.2023, Accepted on 19.05.2023, Published on 20.06.2023
Abstract
ABSTRACT
A few very well-known marketed drugs-Bendamustine, Albendazole, and Mebendazole are studied whether the drugs can bind with two different oligonucleotides or not. Molecular docking study was employed to find the capability of these drugs towards two entirely different DNA sequences. Due to the three-dimensional structures; those drugs are found to bind differentially with DNA duplexes. The other functional possibilities of known drugs with DNA recognitions might be helpful in drug repurposing purposes with the findings of present study.
Keywords: Benzimidazole, AT-rich DNA, GC-rich DNA, Molecular Docking
