Antidiabetic Efficacy of Citrullus colocynthis and Citrullus lanatus: A Review
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Antidiabetic Efficacy of Citrullus colocynthis and Citrullus lanatus: A Review
1Aderiike Adewumi, 2Rufus Animashaun, 3Oluwapelumi Micheal Ajiboye*, and 4Kayode Olusola Ogunwenmo
| Bio-Science Research Bulletin
Volume 39, Number 1 January-June 2023: P.39-51 DOI: 10.48165/bpas.2023.39.1.6 |
| Review Article |
Description
Description
Antidiabetic Efficacy of Citrullus colocynthis and Citrullus lanatus: A Review
1Aderiike Adewumi, 2Rufus Animashaun, 3Oluwapelumi Micheal Ajiboye*, and 4Kayode Olusola Ogunwenmo
Author’s Affiliation:
1Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria
E-mail: adewumia@babcock.edu.ng
2Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria
E-mail: animashaunr@babcock.edu.n
3Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria
E-mail: oluwapelumiajii@gmail.com
4Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria
E-mail: ogunwenmok@babcock.edu.ng
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*Corresponding Author:
Oluwapelumi Micheal Ajiboye
Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria
E-mail: oluwapelumiajii@gmail.com
Received on 20.01.2023
Revised on 23.03.2023
Approved on 17.05.2023
Accepted on 27.05.2023
Published on 19.06.2023
Abstract
ABSTRACT
The present review is focused on the anti-diabetic potential of Citrullus colocynthis and Citrullus lanatus, commonly referred to as bitter apple and watermelon, respectively. The plants have a history of being employed for therapeutic uses and recent investigation has revealed their potential as antidiabetic agents owing to the presence of bioactive compounds, including cucurbitacins, flavonoids, and alkaloids. The present study examines the therapeutic potential of the plants, highlighting their antidiabetic, anti-inflammatory, antioxidant, and hypoglycemic properties. Additionally, the mechanisms responsible for the antidiabetic effects of these substances, and their effectiveness in the treatment of diabetes in animal and human subject. In addition to safety and toxicity, potential adverse effects were also discussed. In conclusion, these plants possess considerable potential as alternative therapies for diabetes. However, additional investigation is required to extensively comprehend their therapeutic efficacy and establish appropriate and safe dosages for clinical application.
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 KEYWORDS: Anti-inflammatory, Antioxidant, Hypoglycemic, Cucurbitacins, Flavonoids, Alkaloids
